APA
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Jang, J., Whitaker, J., Leshem, E., Ngo, L., Neisius, U., Nakamori, S., … Nezafat, R. (2019). Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and Myocardial Wall Thinning. Circulation. Arrhythmia and Electrophysiology.
Chicago/Turabian
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Jang, J., J. Whitaker, E. Leshem, L. Ngo, U. Neisius, S. Nakamori, F. Pashakhanloo, et al. “Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and Myocardial Wall Thinning.” Circulation. Arrhythmia and electrophysiology (2019).
MLA
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Jang, J., et al. “Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and Myocardial Wall Thinning.” Circulation. Arrhythmia and Electrophysiology, 2019.
BibTeX Click to copy
@article{j2019a,
title = {Local Conduction Velocity in the Presence of Late Gadolinium Enhancement and Myocardial Wall Thinning.},
year = {2019},
journal = {Circulation. Arrhythmia and electrophysiology},
author = {Jang, J. and Whitaker, J. and Leshem, E. and Ngo, L. and Neisius, U. and Nakamori, S. and Pashakhanloo, F. and Menze, B. and Manning, W. and Anter, E. and Nezafat, R.}
}
BACKGROUND Conduction velocity (CV) is an important property that contributes to the arrhythmogenicity of the tissue substrate. The aim of this study was to investigate the association between local CV versus late gadolinium enhancement (LGE) and myocardial wall thickness in a swine model of healed left ventricular infarction.
METHODS Six swine with healed myocardial infarction underwent cardiovascular magnetic resonance imaging and electroanatomic mapping. Two healthy controls (one treated with amiodarone and one unmedicated) underwent electroanatomic mapping with identical protocols to establish the baseline CV. CV was estimated using a triangulation technique. LGE+ regions were defined as signal intensity >2 SD than the mean of remote regions, wall thinning+ as those with wall thickness <2 SD than the mean of remote regions. LGE heterogeneity was defined as SD of LGE in the local neighborhood of 5 mm and wall thickness gradient as SD within 5 mm. Cardiovascular magnetic resonance and electroanatomic mapping data were registered, and hierarchical modeling was performed to estimate the mean difference of CV (LGE+/-, wall thinning+/-), or the change of the mean of CV per unit change (LGE heterogeneity, wall thickness gradient).
RESULTS Significantly slower CV was observed in LGE+ (0.33±0.25 versus 0.54±0.36 m/s; P<0.001) and wall thinning+ regions (0.38±0.28 versus 0.55±0.37 m/s; P<0.001). Areas with greater LGE heterogeneity ( P<0.001) and wall thickness gradient ( P<0.001) exhibited slower CV.
CONCLUSIONS Slower CV is observed in the presence of LGE, myocardial wall thinning, high LGE heterogeneity, and a high wall thickness gradient. Cardiovascular magnetic resonance may offer a valuable imaging surrogate for estimating CV, which may support noninvasive identification of the arrhythmogenic substrate.
