Journal article
Circulation. Arrhythmia and electrophysiology, 2018
APA
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Pashakhanloo, F., Herzka, D., Halperin, H., McVeigh, E., & Trayanova, N. (2018). Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models. Circulation. Arrhythmia and Electrophysiology.
Chicago/Turabian
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Pashakhanloo, F., D. Herzka, H. Halperin, E. McVeigh, and N. Trayanova. “Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models.” Circulation. Arrhythmia and electrophysiology (2018).
MLA
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Pashakhanloo, F., et al. “Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models.” Circulation. Arrhythmia and Electrophysiology, 2018.
BibTeX Click to copy
@article{f2018a,
title = {Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models},
year = {2018},
journal = {Circulation. Arrhythmia and electrophysiology},
author = {Pashakhanloo, F. and Herzka, D. and Halperin, H. and McVeigh, E. and Trayanova, N.}
}
Background: An improved knowledge of the spatial organization of infarct structure and its contribution to ventricular tachycardia (VT) is important for designing optimal treatments. This study explores the relationship between the 3-dimensional structure of the healed infarct and the VT reentrant pathways in high-resolution models of infarcted porcine hearts. Methods: Structurally detailed models of infarcted ventricles were reconstructed from ex vivo late gadolinium enhancement and diffusion tensor magnetic resonance imaging data of 8 chronically infarcted porcine hearts at submillimeter resolution (0.25×0.25×0.5 mm3). To characterize the 3-dimensional structure of surviving tissue in the zone of infarct, a novel scar-mapped thickness metric was introduced. Further, using the ventricular models, electrophysiological simulations were conducted to determine and analyze the 3-dimensional VT pathways that were established in each of the complex infarct morphologies. Results: The scar-mapped thickness metric revealed the heterogeneous organization of infarct and enabled us to systematically characterize the distribution of surviving tissue thickness in 8 hearts. Simulation results demonstrated the involvement of a subendocardial tissue layer of varying thickness in the majority of VT pathways. Importantly, they revealed that VT pathways are most frequently established within thin surviving tissue structures of thickness ⩽2.2 mm (90th percentile) surrounding the scar. Conclusions: The combination of high-resolution imaging data and ventricular simulations revealed the 3-dimensional distribution of surviving tissue surrounding the scar and demonstrated its involvement in VT pathways. The new knowledge obtained in this study contributes toward a better understanding of infarct-related VT.